PERMEABILITY TRANSITION
of the mitochondrial inner membrane
Last updated 05 Sep 2000
Our group has been investigating the permeability transition of the mitochondrial inner membrane for many years. Special attention was devoted to the following aspects of this problem:
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Effect of pro- and antioxidants, role of lipid peroxidation |
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Role of thiol groups redox state |
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Effect of calcium and phosphate contents |
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Osmotic pressure effect |
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Age-related changes in the mitochondria permeability transition process |
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Role of ischemic injury |
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Effect of mitochondria cryodamage and reparation after freezing and thawing |
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Effect of thyroid hormones |
You can see the list of our selected publications on the mitochondrial permeability transition
Recently we have started new long-time project (click it to see details):
Mathematical Modeling of the Mitochondrial Permeability Transition
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Our present understanding of interrelations of the main
processes participating in PT is briefly depicted on the GENERAL
SCHEME OF THE MITOCHONDRIAL PERMEABILITY TRANSITION.
See
comments here
(scheme is taken from Andrey Anishkin article
"Mathematical model of the mitochondrial permeability transition: a systemic
approach." (In preparation)).
