GENERAL
SCHEME of
the Mitochondrial Permeability Transition
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scheme
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This scheme represents main processes and influencing
factors involved (directly or indirectly) in the Permeability Transition (PT) of inner mitochondrial
membrane. The purpose of this scheme creation was to give a start
point for the mathematical model of PT working up. The scheme is based on the totality of published
experimental data and reviews related to the subject. In fact
this is something like a graphical review. To provide the base
for depicted PT mechanism a set of browsable links to HTML
documents with references and additional information were
included. (In the nearest time a number of the
references will be prepared and added to the scheme). The
references on mitochondrial permeability transition can be also
found in subject index or alphabetical index.
The scheme is currently (and possibly permanently) in the process of development and
some pats can be revised or supplemented. In particular this
is related to processes involving Adenine Nucleotides
Translocase (ANT) interaction with Voltage Dependent Anion
Channel (VDAC), Peripheral Benzodiazepine Receptor (PBR)
parts, and Bcl-2 family proteins because this area is
obviously at present not well studied experimentally. New
and, possibly, unexpected experimental data could change radically
current conception. Proposed scheme is only one of the
possible variants of PT process organization. It was taken from Andrey Anishkin
article "Mathematical model of the mitochondrial permeability transition: a
systemic approach.", which is in preparation now.
Of course, none scheme could include all the details of
such complex and multifactor process as Mitochondrial
Permeability Transition (especially taking into account that
PT is far from being completely studied experimentally). We
are really appreciate any comments or corrections that on
your opinion should be made to the scheme. Please, contact
us for discussion or for any additional
information.