Bioenergetics and biomembranology materials

Index

	Educational materials
	Reference books
	Research materials
	Conferences materials
	Personal pages
	Software

Educational materials

	Mitochondria Studies The experiments on mitochondria, described here, were designed to augment the student's understanding of how mitochondria function, while providing a hands-on experience. The recommended studies have been carried out successfully on preparations from rat liver.
	3D model gallery You can find here Rat Liver Mitochondrion 3D model and several other interesting models
	Lectures on biological energy conversion (Biophysics 354) Introduces and explores the major mechanisms of energy conversion in biology, with particular emphasis on respiratory and photosynthetic bioenergetics, and the physic-chemical tools required to describe these processes.
	Oxidative Phosphorylation Home Page These pages describe how mitochondria use the energy from substrate oxidation to drive the synthesis of ATP from ADP and inorganic phosphate. The system also powers many cellular transport processes.
	bc1 complex site This site contains information, links, pictures, and down-loadable materials based on research on the bc₁ complex. This group of electron transfer enzymes,- generally known as bc₁ complexes in mitochondria, bacterial respiratory chains and photosynthetic bacteria, or b₆f complexes in the photosynthetic chains of oxygenic photosynthesis,- carries the main flux of energy through the biosphere
	Complex I Home Page The purpose of this site is to provide general information regarding complex I (NADH quinone oxidoreductase) to researchers in the field of bioenergetics as well as to those who are simply curious about what this enzyme complex does.
	Brdiczka Laboratory University of Konstanz, Faculty of Biology, Brdiczka Laboratory. Scientific work concentrates on: Energy transfer and signal transduction between mitochondria and cytosol. On this site you can find some great related educational software.
	Mitochondrial Disease Information The United Mitochondrial Disease Foundation. Glossary of Terms. Literature Reviews. Mitochondria and Disease. Mitochondrial Disease Descriptions. Mitochondrial Disease Publications by UMDF. UMDF Medical Article Database and Library.

Reference books

Ortholog Group of ATP Synthase
Gene map with Amino Acids sequences and brief subunits description for different types of F- and V- ATP(synth)ases

Research materials

	Complex I Home Page The purpose of this site is to provide general information regarding complex I (NADH quinone oxidoreductase) to researchers in the field of bioenergetics as well as to those who are simply curious about what this enzyme complex does.
	The bc1 complex of Rhodobacter sphaeroides site with a number of related links (pictures are not downloaded)
	Cytochrome bc1 project site with research information on this topic
	Brdiczka Laboratory University of Konstanz, Faculty of Biology, Brdiczka Laboratory. Scientific work concentrates on: Energy transfer and signal transduction between mitochondria and cytosol. On this site you can find some great related educational software.
	The Thermosynthesis Home Page Thermosynthesis is a physical theory for the stepwise emergence during evolution of the contemporary biological energy conversion machinery. The basic tenet of the thermosynthesis (TS) theory is that thermal cycling is a major agent in the origin and evolution of life.
	Biochemistry (Moscow) On-Line, World Wide Web version of the international edition of Russian leading scientific journal in the fields of biochemistry and biochemical aspects of molecular biology, bioorganic chemistry, microbiology, immunology, physiology, and biomedical sciences. Some articles available in full text (in HTML)

JD Lab page
Our lab at UT Southwestern. We study the three-dimensional structures of biological macromolecules with the methods of X-ray crystallography. Among the techniques we use are heterologous expression, purification, crystallization, and mutagenesis of proteins, X-ray diffraction, computational crystallography, and structure analysis. Our interests focus on the following main areas: Proteins involved in energy transfer and electron transfer, proteins using light energy, membrane proteins, membrane associating proteins, chaperonins and proteins with repeating sequence motifs.

	Prof. Dr. Ulrich Brandt Complex I
	Theoretical Biophysics group Light Harvesting in Bacterial Photosynthesis

	Andrew Rodgers Home Page Andrew Rodgers studies the FoF1-ATPase, the enzyme complex catalyzing the terminal step in oxidative phosphorylation and photophosphorylation.
	Roderick A. Capaldi Lab Homepage Research focuses on enzymes of oxidative phosphorylation. With high resolution structures already determined for complex III, cytochrome c oxidase and the F1 part of the ATP synthase, it is now possible for the first time to explore the mechanism of oxidative phosphorylation at a detailed molecular level. Primary emphasis has been to understand the workings of the ATP synthase, also called the F1F0-ATPase.
	George Oster. University of California Department of Molecular and Cellular Biology Mathematical modeling of ATP synthase. Bibliography with full-text articles. Software description.
	Hongyun Wang's Home Page (Works with G. Oster) Mathematical modeling of ATP synthase. Bibliography with full-text articles. Links to ATPase work movies - more than 20!!! (in MPEG and AVI format).
	GEPASI (developed by Pedro Mendes) a user- friendly MS- Windows computer program to simulate the dynamics of biochemical systems, with an emphasis on the steady- state properties of pathways containing enzymes that interact by transferring their intermediate metabolite directly (metabolic channelling).
	METABOLOMICS IN ABERYSTWYTH Whilst there is much current interest in the genome-wide analysis of cells at the level of transcription (to define the 'transcriptome') and translation (to define the 'proteome'), the third level of analysis, that of the 'metabolome', has been curiously unexplored to date. The term 'metabolome' refers to the entire complement of all the small molecular weight metabolites inside a cell suspension (or other sample) of interest. It is likely that measurement of the metabolome in different physiological states will in fact be much more discriminating for the purposes of functional genomics.

Conferences materials

The 1996 Albany Conference: Frontiers of Mitochondrial Research
September 19-22, 1996 Rensselaerville, New York

	The 1997 Albany Conference: Biomolecular Motors and Nanomachines September 4-7, 1997 Rensselaerville, New York
	Frontiers of Mitochondrial Research 2nd Albany Conference, September 24-27, 1998 Rensselaerville, NY
	XIth International Congress on Photosynthesis August 17-22, Budapest, Hungary

Personal pages

ANTONY RICHARD CROFTS homepage
Bioenergetics, respiratory chain, microbiology.

	M.Yagi Lab's Home Page Oxidative phosphorylation, Complex I
	Y. Hatefi Lab Homepage Bioenergetics in Mitochondria and Bacteria, CYTOCHROME c OXIDOREDUCTASE
	Brdiczka Laboratory University of Konstanz, Faculty of Biology, Brdiczka Laboratory. Scientific work concentrates on: Energy transfer and signal transduction between mitochondria and cytosol. On this site you can find some great related educational software.
	Graham Palmer homepage Laboratory is involved in the characterization of two of these enzymes, the ubiquinol cytochrome c oxidoreductase (Complex III) and cytochrome oxidase (Complex IV). The experimental approach depends on the application of spectroscopic and other physical methods, in conjunction with transient state kinetic experiments, to define the structures and dynamics of the species which function in the electron transport, and to a lesser extent, the proton translocation reactions.
	Peter Nicholls Homepage Oxidative enzymes and the bioenergetics of membrane systems, studying catalase and cytochrome c oxidase
	Chang-An Yu homepage Structure/function of membrane proteins; biocatalysis, Q-cycle
	Prof. Dr. G. Hauska Homepage Principles of Energy Conservation in the Electron Transport Chains of Photosynthesis and Respiration
	BERNARD L. TRUMPOWER, PROFESSOR OF BIOCHEMISTRY BIOCHEMISTRY AND GENETICS OF RESPIRATION We are investigating several aspects of the mitochondrial cytochrome bc1 complex, including identifying electron transfer pathways within individual proteins by site directed mutagenesis combined with kinetics measurements on a msec time scale of mutated enzymes.

	Prof. Dr. Ulrich Brandt Complex I
	Theoretical Biophysics group Light Harvesting in Bacterial Photosynthesis
	Roderick A. Capaldi Lab Homepage Research focuses on enzymes of oxidative phosphorylation. With high resolution structures already determined for complex III, cytochrome c oxidase and the F1 part of the ATP synthase, it is now possible for the first time to explore the mechanism of oxidative phosphorylation at a detailed molecular level. Primary emphasis has been to understand the workings of the ATP synthase, also called the F1F0-ATPase.
	Andrew Rodgers Home Page Andrew Rodgers studies the FoF1-ATPase, the enzyme complex catalyzing the terminal step in oxidative phosphorylation and photophosphorylation.

Software

Electronic courses of Metabolic regulation, bioenergetics, mitochondria structure lectures from D. Brdiczka Laboratory (University of Konstanz Faculty of Biology).