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ANT

Adenine nucleotides effect

Andreeva L , Tanveer A , Crompton M. / Evidence for the involvement of a membrane-associated cyclosporin-A- binding protein in the Ca(2+)-activated inner membrane pore of heart mitochondria. // Eur J Biochem, - 1995 Jun 15, - 230. - pp.1125-32.    [MEDLINE]

Connern CP, Halestrap AP. / Chaotropic agents and increased matrix volume enhance binding of mitochondrial cyclophilin to the inner mitochondrial membrane and sensitize the mitochondrial permeability transition to [Ca2+]. // Biochemistry, - 1996 Jun 25, - 35. - pp.8172-80.    [MEDLINE]

Crompton M. / The mitochondrial permeability transition pore and its role in cell death. // Biochem J, - 1999 Jul 15, - 341 ( Pt 2). - pp.233-49.    [MEDLINE]

Crompton M , Costi A. / A heart mitochondrial Ca2(+)-dependent pore of possible relevance to re- perfusion-induced injury. Evidence that ADP facilitates pore interconversion between the closed and open states. // Biochem J, - 1990 Feb 15, - 266. - pp.33-9.    [MEDLINE]

Friberg H, Connern C, Halestrap AP, Wieloch T. / Differences in the activation of the mitochondrial permeability transition among brain regions in the rat correlate with selective vulnerability. // J Neurochem, - 1999 Jun, - 72. - pp.2488-97.    [MEDLINE]

Halestrap AP, Connern CP, Griffiths EJ, Kerr PM. / Cyclosporin A binding to mitochondrial cyclophilin inhibits the permeability transition pore and protects hearts from ischaemia/reperfusion injury. // Mol Cell Biochem, - 1997 Sep, - 174. - pp.167-72.    [MEDLINE]

Halestrap AP, Kerr PM, Javadov S, Woodfield KY. / Elucidating the molecular mechanism of the permeability transition pore and its role in reperfusion injury of the heart. // Biochim Biophys Acta, - 1998 Aug 10, - 1366. - pp.79-94.    [MEDLINE]

Halestrap AP, Woodfield KY, Connern CP. / Oxidative stress, thiol reagents, and membrane potential modulate the mitochondrial permeability transition by affecting nucleotide binding to the adenine nucleotide translocase. // J Biol Chem, - 1997 Feb 7, - 272. - pp.3346-54.    [MEDLINE]

Henke W , Hagen T , Jung K , Loening SA. / Periodate-oxidized ATP stimulates the permeability transition of rat liver mitochondria. // Biochim Biophys Acta, - 1998 Mar 25, - 1363. - pp.209-16.    [MEDLINE]

Koretsune Y, Marban E. / Mechanism of ischemic contracture in ferret hearts: relative roles of [Ca2]i elevation and ATP depletion. // Am J Physiol, - 1990 Jan, - 258. - pp.H9-16.    [MEDLINE]

Leyssens A , Nowicky AV , Patterson L , Crompton M , Duchen MR. / The relationship between mitochondrial state, ATP hydrolysis, [Mg2+]i and [Ca2+]i studied in isolated rat cardiomyocytes. // J Physiol (Lond), - 1996 Oct 1, - 496 ( Pt 1). - pp.111-28.    [MEDLINE]

Stoner CD, Sirak HD. / Adenine nucleotide-induced contraction on the inner mitochondrial membrane. II. Effect of bongkrekic acid. // J Cell Biol, - 1973 Jan, - 56. - pp.65-73.    [MEDLINE]

Tanveer A , Virji S , Andreeva L , Totty NF , Hsuan JJ , Ward JM , Crompton M. / Involvement of cyclophilin D in the activation of a mitochondrial pore by Ca2+ and oxidant stress. // Eur J Biochem, - 1996 May 15, - 238. - pp.166-72.    [MEDLINE]

"m" and "c" ANT conformations role

Halestrap AP, Woodfield KY, Connern CP. / Oxidative stress, thiol reagents, and membrane potential modulate the mitochondrial permeability transition by affecting nucleotide binding to the adenine nucleotide translocase. // J Biol Chem, - 1997 Feb 7, - 272. - pp.3346-54.    [MEDLINE]

Henke W , Hagen T , Jung K , Loening SA. / Periodate-oxidized ATP stimulates the permeability transition of rat liver mitochondria. // Biochim Biophys Acta, - 1998 Mar 25, - 1363. - pp.209-16.    [MEDLINE]

Le Quoc K , Le Quoc D. / Involvement of the ADP/ATP carrier in calcium-induced perturbations of the mitochondrial inner membrane permeability: importance of the orientation of the nucleotide binding site. // Arch Biochem Biophys, - 1988 Sep, - 265. - pp.249-57.    [MEDLINE]

Stoner CD, Sirak HD. / Adenine nucleotide-induced contraction on the inner mitochondrial membrane. II. Effect of bongkrekic acid. // J Cell Biol, - 1973 Jan, - 56. - pp.65-73.    [MEDLINE]

K+ - permeability of ANT

Halestrap AP. / The regulation of the matrix volume of mammalian mitochondria in vivo and in vitro and its role in the control of mitochondrial metabolism. // Biochim Biophys Acta, - 1989 Mar 23, - 973. - pp.355-82.    [MEDLINE]

PT pore interaction with cyclophilin

Andreeva L , Tanveer A , Crompton M. / Evidence for the involvement of a membrane-associated cyclosporin-A- binding protein in the Ca(2+)-activated inner membrane pore of heart mitochondria. // Eur J Biochem, - 1995 Jun 15, - 230. - pp.1125-32.    [MEDLINE]

Connern CP, Halestrap AP. / Chaotropic agents and increased matrix volume enhance binding of mitochondrial cyclophilin to the inner mitochondrial membrane and sensitize the mitochondrial permeability transition to [Ca2+]. // Biochemistry, - 1996 Jun 25, - 35. - pp.8172-80.    [MEDLINE]

Crompton M , Andreeva L. / On the interactions of Ca2+ and cyclosporin A with a mitochondrial inner membrane pore: a study using cobaltammine complex inhibitors of the Ca2+ uniporter. // Biochem J, - 1994 Aug 15, - 302 ( Pt 1). - pp.181-5.    [MEDLINE]

Crompton M, Virji S, Ward JM. / Cyclophilin-D binding proteins. // Biochem Soc Trans, - 1998 Nov, - 26. - pp.S330.    [MEDLINE]

Crompton M, Virji S, Ward JM. / Cyclophilin-D binds strongly to complexes of the voltage-dependent anion channel and the adenine nucleotide translocase to form the permeability transition pore. // Eur J Biochem, - 1998 Dec 1, - 258. - pp.729-35.    [MEDLINE]

Doyle V, Virji S, Crompton M. / Evidence that cyclophilin-A protects cells against oxidative stress. // Biochem J, - 1999 Jul 1, - 341 ( Pt 1). - pp.127-32.    [MEDLINE]

Doyle V, Virji S, Crompton M. / Suppression of cyclophilin-A activity in rat cardiomyocytes. // Biochem Soc Trans, - 1998 Nov, - 26. - pp.S328.    [MEDLINE]

Ferrand-Drake M, Friberg H, Wieloch T. / Mitochondrial permeability transition induced DNA-fragmentation in the rat hippocampus following hypoglycemia. // Neuroscience, - 1999, - 90. - pp.1325-38.    [MEDLINE]

Friberg H, Connern C, Halestrap AP, Wieloch T. / Differences in the activation of the mitochondrial permeability transition among brain regions in the rat correlate with selective vulnerability. // J Neurochem, - 1999 Jun, - 72. - pp.2488-97.    [MEDLINE]

Friberg H, Ferrand-Drake M, Bengtsson F, Halestrap AP, Wieloch T. / Cyclosporin A, but not FK 506, protects mitochondria and neurons against hypoglycemic damage and implicates the mitochondrial permeability transition in cell death. // J Neurosci, - 1998 Jul 15, - 18. - pp.5151-9.    [MEDLINE]

Halestrap AP, Connern CP, Griffiths EJ, Kerr PM. / Cyclosporin A binding to mitochondrial cyclophilin inhibits the permeability transition pore and protects hearts from ischaemia/reperfusion injury. // Mol Cell Biochem, - 1997 Sep, - 174. - pp.167-72.    [MEDLINE]

Halestrap AP , Davidson AM. / Inhibition of Ca2(+)-induced large-amplitude swelling of liver and heart mitochondria by cyclosporin is probably caused by the inhibitor binding to mitochondrial-matrix peptidyl-prolyl cis-trans isomerase and preventing it interacting with the adenine nucleotide translocase. // Biochem J, - 1990 May 15, - 268. - pp.153-60.    [MEDLINE]

Halestrap AP, Kerr PM, Javadov S, Woodfield KY. / Elucidating the molecular mechanism of the permeability transition pore and its role in reperfusion injury of the heart. // Biochim Biophys Acta, - 1998 Aug 10, - 1366. - pp.79-94.    [MEDLINE]

Halestrap AP, Woodfield KY, Connern CP. / Oxidative stress, thiol reagents, and membrane potential modulate the mitochondrial permeability transition by affecting nucleotide binding to the adenine nucleotide translocase. // J Biol Chem, - 1997 Feb 7, - 272. - pp.3346-54.    [MEDLINE]

Igbavboa U , Zwizinski CW , Pfeiffer DR. / Release of mitochondrial matrix proteins through a Ca2+-requiring, cyclosporin-sensitive pathway. // Biochem Biophys Res Commun, - 1989 Jun 15, - 161. - pp.619-25.    [MEDLINE]

Johnson N, Khan A, Virji S, Ward JM, Crompton M. / Import and processing of heart mitochondrial cyclophilin D. // Eur J Biochem, - 1999 Jul, - 263. - pp.353-9.    [MEDLINE]

Khaspekov L, Friberg H, Halestrap A, Viktorov I, Wieloch T. / Cyclosporin A and its nonimmunosuppressive analogue N-Me-Val-4- cyclosporin A mitigate glucose/oxygen deprivation-induced damage to rat cultured hippocampal neurons. // Eur J Neurosci, - 1999 Sep, - 11. - pp.3194-8.    [MEDLINE]

Matsumoto S, Friberg H, Ferrand-Drake M, Wieloch T. / Blockade of the mitochondrial permeability transition pore diminishes infarct size in the rat after transient middle cerebral artery occlusion. // J Cereb Blood Flow Metab, - 1999 Jul, - 19. - pp.736-41.    [MEDLINE]

Novgorodov SA , Gudz' TI , Zorov DB , Kushnareva IuE , Kudriashov IuB. / [The effect of cyclosporin A and oligomycin on the nonspecific permeability of the mitochondria inner membrane] // Biokhimiia, - 1991 Mar, - 56. - pp.529-35.    [MEDLINE]

Novgorodov SA , Gudz' TI , Kushnareva IuE , Zorov DB , Kudriashov IuB. / [The role of the ADP/ATP-antiporter in the inhibition of nonspecific permeability of the inner mitochondrial membrane by cyclosporin A] // Biokhimiia, - 1991 Mar, - 56. - pp.536-41.    [MEDLINE]

Pastorino JG , Chen ST , Tafani M , Snyder JW , Farber JL. / The overexpression of Bax produces cell death upon induction of the mitochondrial permeability transition. // J Biol Chem, - 1998 Mar 27, - 273. - pp.7770-5.    [MEDLINE]

Petersen A, Castilho RF, Hansson O, Wieloch T, Brundin P. / Oxidative stress, mitochondrial permeability transition and activation of caspases in calcium ionophore A23187-induced death of cultured striatal neurons. // Brain Res, - 2000 Feb 28, - 857. - pp.20-29.    [MEDLINE]

Schild L, Matthias R, Stanarius A, Wolf G, Augustin W, Halangk W. / Induction of permeability transition in pancreatic mitochondria by cerulein in rats [In Process Citation] // Mol Cell Biochem, - 1999 May, - 195. - pp.191-7.    [MEDLINE]

Tanveer A , Virji S , Andreeva L , Totty NF , Hsuan JJ , Ward JM , Crompton M. / Involvement of cyclophilin D in the activation of a mitochondrial pore by Ca2+ and oxidant stress. // Eur J Biochem, - 1996 May 15, - 238. - pp.166-72.    [MEDLINE]

Woodfield K, Ruck A, Brdiczka D, Halestrap AP. / Direct demonstration of a specific interaction between cyclophilin-D and the adenine nucleotide translocase confirms their role in the mitochondrial permeability transition. // Biochem J, - 1998 Dec 1, - 336 ( Pt 2). - pp.287-90.    [MEDLINE]

Membrane potential effect on PT pore opening

Connern CP, Halestrap AP. / Chaotropic agents and increased matrix volume enhance binding of mitochondrial cyclophilin to the inner mitochondrial membrane and sensitize the mitochondrial permeability transition to [Ca2+]. // Biochemistry, - 1996 Jun 25, - 35. - pp.8172-80.    [MEDLINE]

Halestrap AP, Connern CP, Griffiths EJ, Kerr PM. / Cyclosporin A binding to mitochondrial cyclophilin inhibits the permeability transition pore and protects hearts from ischaemia/reperfusion injury. // Mol Cell Biochem, - 1997 Sep, - 174. - pp.167-72.    [MEDLINE]

Halestrap AP, Kerr PM, Javadov S, Woodfield KY. / Elucidating the molecular mechanism of the permeability transition pore and its role in reperfusion injury of the heart. // Biochim Biophys Acta, - 1998 Aug 10, - 1366. - pp.79-94.    [MEDLINE]

Halestrap AP, Woodfield KY, Connern CP. / Oxidative stress, thiol reagents, and membrane potential modulate the mitochondrial permeability transition by affecting nucleotide binding to the adenine nucleotide translocase. // J Biol Chem, - 1997 Feb 7, - 272. - pp.3346-54.    [MEDLINE]

Impact of ANT on the energy coupling

Kholodenko BN , Zhilinskene VIu , Borutaite VI , Ivanovene LI , Toleikis AI. / [The role of adenine nucleotide translocator in the regulation of oxidative phosphorylation in heart mitochondria] // Biokhimiia, - 1988 Jun, - 53. - pp.1009-12.    [MEDLINE]

Uncoupling protein

Aquila H, Link TA, Klingenberg M. / The uncoupling protein from brown fat mitochondria is related to the mitochondrial ADP/ATP carrier. Analysis of sequence homologies and of folding of the protein in the membrane. // EMBO J, - 1985 Sep, - 4. - pp.2369-76.    [MEDLINE]

Rial E , Poustie A , Nicholls DG. / Brown-adipose-tissue mitochondria: the regulation of the 32000-Mr uncoupling protein by fatty acids and purine nucleotides. // Eur J Biochem, - 1983 Dec 1, - 137. - pp.197-203.    [MEDLINE]

Rial E , Nicholls DG. / The regulation of the proton conductance of brown fat mitochondria. Identification of functional and non-functional nucleotide-binding sites. // FEBS Lett, - 1983 Sep 19, - 161. - pp.284-8.    [MEDLINE]

Reviews

Connern CP, Halestrap AP. / Chaotropic agents and increased matrix volume enhance binding of mitochondrial cyclophilin to the inner mitochondrial membrane and sensitize the mitochondrial permeability transition to [Ca2+]. // Biochemistry, - 1996 Jun 25, - 35. - pp.8172-80.    [MEDLINE]

Crompton M. / The mitochondrial permeability transition pore and its role in cell death. // Biochem J, - 1999 Jul 15, - 341 ( Pt 2). - pp.233-49.    [MEDLINE]

Halestrap AP, Connern CP, Griffiths EJ, Kerr PM. / Cyclosporin A binding to mitochondrial cyclophilin inhibits the permeability transition pore and protects hearts from ischaemia/reperfusion injury. // Mol Cell Biochem, - 1997 Sep, - 174. - pp.167-72.    [MEDLINE]

Panov AV. / [Regulation of the specific and nonspecific ion conductivity of mitochondria by adenine nucleotide carriers] // Biokhimiia, - 1992 Apr, - 57. - pp.483-94.    [MEDLINE]

 

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