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CURRICULUM VITAE

 

PERSONAL DATA

 

Surname:                                              Lemeshko

First and middle names:                     Viktor

Sex:                                                        M

Place of birth:                                      Makhmud-Mekteb, Stavropolian Region, Russia

Nationality:                                          Ukrainian

Date of birth (Y-M-D):                       46-10-23

Home address:                                    Cl. 48C, No 66-91, apto. 1102

                                                               Ed. Torrenza III, Medellin

Phone:                                                  +57-4-260 75 75 ext. 327

E-mail:                                                   vvasilie@perseus.unalmed.edu.co

 

LABOUR DATA

 

Institution:                                           Departamento de Fisica, Universidad Nacional de

                                                               Colombia, Sede Medellin, AA 3840, Medellin

Phone:                                                  +57-4-260 75 75 ext. 327

Fax:                                                        +57-4-260 44 89

email:                                                     vvasilie@perseus.unalmed.edu.co

 

EDUCATION (Highest degrees)

(University or equivalent)

 

       Radio-Physics Faculty, Kharkov State University, Ukraine (1965-1970), Biophysicist.

       Ph. D., biochemistry (Scientific Research Institute of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, 1970-1973).

       Postdoc in Biol. Sci., biophysics (Doctor of Biological Sciences, Kharkov State University, Ukraine, 1975-1983).

 

Participation in Conferences (the most important from 50):

 

       IV International Biophysical Congress, 1972.

       Symposium “Molecular and cellular mechanisms of ageing”, USSR, 1981.

       Symposium “Mitochondria, mechanisms of coupling and regulation”, USSR, 1981.

       First All-Union Biophysical Congress, USSR, 1982.

       Conference “Cytochrome P-450 and human inner medium defense” USSR, 1985.

       III Symposium of the International Society for Heart Research, 1986.

       Symposium “Molecular mechanisms and regulation of energy metabolism”,  USSR, 1986.

       International conference “Achievements and perspectives of cryobiology and cryomedicine”, 1988.

       All-Union Conference “Biochemistry for medicine”, USSR, 1988.

       All-Union Conference “Organism’s endocrine system and environmental harmful factors”, USSR, 1991.

       International conference “Achievements of the contemporary cryobiology”, 1992.

       First Ukrainian Biophysical Congress, 1994.

       II National Congress of Gerontologists and Geriatres”, Ukraine, 1994.

       Symposium “Biological mechanisms of ageing”, Ukraine, 1994.

       I National Biophysical Congress of Colombia, 1997.

       II National Biophysical Congress of Ukraine, 1998

.

SCIENTIFIC EMPLOYMENT

 

Primary Specialty - biophysics

Total time spent on lecturing - over 20 years

Professional Career within the last 15 years

 1984 -    Chief of the Laboratory of Biochemistry and Biophysics, Scientific

                Research Institute of Biology, Kharkov State University, Ukraine.

 1985 -    Head of the Molecular and Applied Biophysics Department,

                Chief of the Laboratory of Biochemistry and Biophysics, Scientific

                Research Institute of Biology, Kharkov State University, Ukraine.

 1987 -    University professor (title) of molecular and applied biophysics

 1988 -    Director of Scientific Research Institute of Biology,

                Head of the Molecular and Applied Biophysics Department,

                Kharkov State University, Ukraine.

 1992 -    Director of Scientific Research Institute of Biology,

                Head of the General and Medical Biophysics Department,

                 Kharkov State University, Ukraine.

 1996 -    Associate Professor of the National University of Colombia, Medellin.

 

RESEARCH EXPERIENCE

List of persons who have obtained scientific degrees Ph.D. under

supervision of the applicant including the titles of thesis's:

 

1.     Yu.V.Nikitchenko "Age-depending changes and regulation peculiarity of biomembranes lipoperoxidation in rat liver and heart". - 1985.

2.     Pascal Malanda "Bioenergetic mechanisms disturbances in mitochondria membranes under total ischemie of heart and liver of different age rats". - 1988.

3.     E.G.Dorkina "Lipoperoxidation under tetracicline damage of different age rats liver and its correction by silibore" - 1990. prof. Yu.K.Vasilenko - co-supervisor).

4.     T.N.Ovsiannikova "Lipid peroxidation under air high temperature and physical activity influences on organism" - 1992.

5.     L.I.Belostotskaya "Phosphorylating and free oxidation in liver mitochondria during ageing" - 1992.

6.     N.G.Mironova "Age peculiarities of rat liver mitochondria cryodamage and reparation after freezing and thawing" - 1993.

7.     V.E.Shekh "Age peculiarities and mechanisms of activation of intermembrane electron transfer in rat liver mitochondria" - 1993.

8.     E.A.Udovikova " Structural and functional coupling of rat liver mitochondria under ageing" - 1995.

9.     A.L.Sukhodub "Influence of some xenobiotics on the structural and functional changes of liver microsomal membranes of different age rats" - 1997.

10.  V.N. Dzuba "Age peculiarities of ischemia effect on mitochondrial structural-functional state and lipid peroxidation of rat heart" - 1998.

11.  A.G.Anishkin "Mathematical description and computer analysis of proton-chemical and chemiosmotic mechanisms of energy coupling" - 1999.

 

State research grants (for the last 8 years):

 

1.   Elaboration of experimental model of optical-dielectric gauge for determination of blood cells hemo-coagulative properties. (Grant of GKNO of USSR, 1992)

2.   Investigation of lipoperoxidative mechanism of membrane ischemic damage and elaboration of a new membrane protectors. (Grant of Ukraine, Education Ministry, 1992)

3.   Investigation of the role of the outer membrane and high-amplitude swelling of mitochondria in mechanisms of accelerated aging. (Grant of GKNT of Ukraine, 1992, registry. 01.06.02/017).

4.   Investigation of organism ageing molecular mechanism at the level of the Ca2+/hydroperoxide-dependent regulation of structural and metabolic state of mitochondria. (Grant of GKNT of Ukraine, 1992, registry. 5/149).

5.   Investigation of the role of mitochondria metabolic changes in the mechanism of ischemic lipoperoxidative damage of myocardial membranes. (Grant of DKNT of Ukraine, 1994, registry. 01.03.00/215 -94).

6.   Investigation of the mechanisms of age changes in regulation of inner membrane nonspecific permeability and the activity of the outer pathway of NADH oxidation. (Grant of DKNT of Ukraine, 1994, registry. N5.3/325)

7.   Mitochondrial damages under the induction of the inner membrane permeability transition  and prevention by antioxidants. (Project N1118-05-286-96 of Colciencias, 1998-2000, Colombia).

 

Field of scientific interests:

 

       Oxidative phosphorylation mechanism, permeability and structural state of  mitochondrial membranes.

       Bioenergetic and biomembrane mechanisms of ageing.

       Lipid peroxidation and its regulation in cells.

       Mechanisms of ischemic damage of biomembranes.

       Monooxygenase system and membrane damages by xenobiotics

 

List of scientific papers (except thesis's):

 

1.          Lemeshko V.V.,Gubski V.I., Protsenko V.N. Method for the simultaneous study of respiration and fluorescence of the NAD/NADH system of mitochondria. // Sovremen. Probl. Biokhim. Dihaniya i Klinika. l97l, v. l, p. 132-134.

2.          Gubskii V.I., Protsenko V.N., Lemeshko V.V. Effect of severe mechanical trauma on the state of tissue ox-red reactions. // Voprosi Med. Khimii, 1972, v. 18, N 6, p. 587-591.

3.          Belous A.M., Lemeshko V.V. Comparative characteristics of the action of PEG-400 and glicerole on the functional state of mitochondria . // Akt. Vopr. Konserv. i Transpl. Kostnogo Mozga i Krovi, l972. p. 123-129.

4.          Lemeshko V.V., Belous A.M. Action of the deep freezing on oxidative phosphorylation, respiration and NADH fluorescence of rat liver homogenates. // Akt. Vopr. Konserv. i Transpl. Kostnogo Mozga i Krovi, l972, p. 147-15l.

5.          Lemeshko V.V., Belous A.M. Application of glycerol for prevention affection of rat liver mitochondria under deep freezing. // Ukr. Biokhim. Zhurnal, l974, v. 46, N l, p. l85-l87.

6.          Subbota N.P., Lemeshko V.V. Functional state of mitochondria (in homogenates) under freezing-thawing of slices of renal cortex. // Akt. Vopr. Kriobiol. i Kriomed., Kiev: Naukova Dumka, 1974, p. 90-92.

7.          Lemeshko V.V. Study of the rate of polyethyleneglicols penetration through mitochondrial membranes. // Akt. Vopr. Kriobiol. i Kriomed. l974. Kiev: Edit. Nauka Dumka. p. 58-60.

8.          Belous A.M., Lemeshko V.V., Bonderenko V.A. Influence of freezing-thawing on the rat liver mitochondria chemiluminescence kinetic. // Akt. Vopr. Kriobiol. i Kriomed. , Kiev: Edit. Naukova Dumka, l974, p. 38-41.

9.          Bilous A.M., Lemeshko V.V. Oxidative phosphorylation in mitochondria of rat liver under deep freezing and defrostation. // Ukr. Biokhim. Zhurnal. l974, v. 46, N 3, p . 368-37l .

10.       Lemeshko V.V., Chaplai E.V. Activation of glucose-6-phosphatase under freezing in rat liver. // Kriobiol. i Kriomedicine. Kiev: Edit. Naukova Dumka, N l, l975, p. 66-67.

11.       Lemeshko V.V., Belous A.M., Mishneva L.G. Influence of cryoprotectors (glicerole and PEG-400) on respiratory chain of rat liver mitochondria. // Kriobiol. i Kriomedicina., Kiev: Edit. Naukova Dumka, l975, N l, p. 67-70.

12.       Lemeshko V.V. Functional state of rat liver mitochondria at different phases of slow freezing and storage at -25 C. // Biol. Nauki. N 2, l975. p. 56-60.

13.       Bondarenko V.A., Lemeshko V.V., Belous A.M. Effects of different regimes of freezing and thawing on chemiluminescence of rat liver mitochondria. // Ukr. Biokhim. Zhurnal, l975, v. 47, N 6. p. 743-746.

14.       Belous A.M., Lugovoy V.I., Lemeshko V.V., Bondarenko V.V., Grek A.M., Gulevskii O.K Provlemi Kriobioximii.// Bull. AN UkrSSR, l976, N 2, p. 38-48.

15.       Lemeshko V.V., Bondarenko V.A., Suvvota N.P., Belous A.M. Cryodamage and cryoprotection of mitochondria in vitro and in vivo.// Kriobiol. i Kriomedicina, Kiev: Edit. Naukova Dumka, l976, N 2, p. 33-37.

16.       Nardin O.A., Moiseev V.A., Lemeshko V.V. Effects of “the biometals” chelation by poliethyleneglicols. // Kriobiol. i Kriomedicina, Kiev: Edit. Naukova Dumka. l976, N 2, p. 19-21.

17.       Imseneski A.A., Lisenko S.V., Murzakov B.G., Blokhin V.A., Lemeshko V.V. Application of hydroperite in reactions of chemiluminescent determination of iron-porphyrin proteins. // Mikrobiologia, l976, v.65, p. 735-737.

18.       Belous A.M., Lemeshko V.V., Yasaitis A.A. Halidor, l-benzyl-l-(3`-dimethylaminopropoxy)-cycloheptane fumarate as uncoupler and inhibitor of the respiratoty chain. // Biokhimiya, l976, v. 4l, N 5, p. 88l-885.

19.       Bonderenko V.A., Lemeshko V.V., Belous A.M. Structural damage of mitochondrial membrane under freezing-thawing. // Kriobiol. i Kriomedicina, l977, N 3. p. 41-43.

20.       Chuiko V.A., Gazii T.V., Lemeshko V.V., Kalko A.I. The electrical activity of the heart of the fish hypophthalmichtus molitrix during cooling and warming. // Zhurnal Evol. Biokhimii i Fiziologii, l977, v. 13, p. 9l-94.

21.       Imshenetsky A.A., Murzakov B.G., Blokhin V.A., Lisenko S.V., Lemeshko V.V.,Tserkovny A..I., Belous A.M. Optimal conditions for determination of ATP of microbial origin. // Mikrobiologia, l977, v. 66 , N 2, p. 277-282.

22.       Lemeshko V.V. The preservation of the functional activity of mitochondria under deep freezing. // Mitochondria, energy accumulation and regulation of enzymatic processes.Moscow: Edit. Nauka, l977, p. 5-ll.

23.       Sakhnovich V.M., Lemeshko V.V. Use of energy dependent ox-red transitions of pyridinenucleotides for evaluation of the kidney viability after its perfusion and freezing-thawing. // Cryobiol. i Cryomed. l978, N 4, p. 22-25.

24.       Lemeshko V.V., Kudokotseva E.V., Belous A.M. Cryoresistance of rat liver endoplasmic reticulum membranes. // Biokhimia, l978, v. 43, N l, p. 72-77.

25.       Lemeshko V.v., Kaliman P.A. Decrease of the mitochondria outer membrane strength during ageing. Replacement of the mitochondria populations. // Dokl. AN SSSR, 1978, v. 243, N 6, p. 1579-1580.

26.       Belous A.M., Lemeshko V.V., Kudokotseva O.V., Mishnova L.G., Subbota N.P. Biochemical changes of membranous electron transport systems (redox chains) under freezing. // Bull. AN UkrSSR, l979, N l, p. 24-31.

27.       Lemeshko V.V., Nazarenko H.D. Lipid peroxidation in liver homogenates of rats of different age.// Akt. Probl. Vozrastnoi Fisiol. , Biokhim. i Biofiz. Kiev: Edit. Naukova Dumka. l979. p. 131-138.

28.       Lemeshko V.V., Kaliman P.A., Petrenko A.Y. Cytochromes content in liver microsomes of rats of different age in norm and after hormone injections (thyroxin and hydrocortizone). // Akt. Probl. Vostrastnoi Fisiol. Biokhim. i Biofiz., Kiev: Edit. Naukova Dumka. l979. p. l25-130.

29.       Lemeshko V.V., Kaliman P.A. Changes in cytochrome c and a(a3) contents in rat liver mitochondria under hyperthyroidism. // Bull. Eksperim. Biologii i Medicini, 1980, v. 89, N 2, p. 174-176.

30.       Lemeshko V.V., Kaliman P.A. Age peculiarity of the thyroxine effect on cytochromes content in liver mitochondria and body mass of rats. // Vopr. Med. Khimii, 1980, N 5. p. 632-636.

31.       Lemeshko V.V. Phosphite-thiol-electrochemical mechanism of oxidative phosphorylation in redox-chain of biomembranes. // Dokl. AN UkrSSR. Series B., 1980, N 10, p. 78-80.

32.       Lemeshko V.V. The system of microsomal oxidation during development and ageing. // Biokhimia, 1980, v. 45, N 11, p. 1964-1969.

33.       Lemeshko V.V. Enzymatic lipid peroxidation of liver microsomal membranes of rats of different ages after thyroxine and hydrocortisone injections. // Fisiol. i Biokhim. Vozrastn. Rasvitia, Kiev: Edit. Naukova Dumka. l980. p. 147-150.

34.       Lemeshko V.V., Kaliman P.A Age peculiarity of the thyroxine action on tissue respiration , oxidative phosphorylation and ATPase activity of heart and liver mitochondria. // Fisiologia i Biokhim. Vozrastn. Rasvitia, Kiev: Edit. Naukova Dumka, l980, p. 125-136.

35.       Lemeshko V.V. Hypothetical phosphit-thiol molecular mechanism for the functioning of Na/K- and Ca2-pumps of biomembranes. // Dokl. AN SSSR. l98l. v. 259, N l, p. 232-234.

36.       Kaliman P.A., Lemeshko V.V., Petrenko V.V. Role of glycerophosphate shuttle in regulation of cytoplasmic NADH oxidation and ATP synthesis by rat liver mitochondria in ontogenesis. // Ukr. Biokhim. Zhurnal, 1981, v. 53, N 1, p. 35-38.

37.       Lemeshko V.V., Kaliman P.A., Nikitchenko Yu.V. Age peculiarity of the lipid peroxidation in rat liver. // Dokl. AN UkrSSR. Series B., 1981, N 2, p. 81-83.

38.       Lemeshko V.V., Kaliman P.A., Nikitchenko Y.V., Lipid peroxidation in postnuclear and microsomal fractions of rat liver homogenates during ageing. // Biokhimia . l98l, v. 46, N 620-627.

39.       Lankin B.Z., Tixaze A.K., Kovalevskia A.L., Lemeshko V.V., Vixert A.M. Age changes of glutathione S-transferase and glutathione peroxidase activities in rat liver. // Dokl. AN SSSR. l98l, v. 26l, N 6, p. 1467-1470.

40.       Lemeshko V.V. Possible participation of phosphite-thiol and thiol-disulfide transitions in the mechanism of muscular contraction. // Dokl. AN UkrSSR. Serie B., l98l,. N 7, p. 65-66.

41.       Lankin V.Z., Tikhaze A.K., Lemeshko V.V., Shermatov K., Kaliman P.A., Vikhert. Age associated changes in superoxide dismutase and glutathione peroxidase activity of rat liver cytosol and mitochondria. // Bull. Eksperim. Biologii i Medicini, l98l, N 9. p. 3l0-3ll.

42.       Lemeshko V.V. Effect of thyroxine on the NADH-cytochrome c reductase activity of microsomes and outer mitochondrial membrane of rat liver mitochondria. // Biokhimia, 1981, v. 46, N 10, 1807-1814.

43.       Lemeshko V.V., Tovstiak V.V., Kovgan L.N. Relationship between electrokinetic and transmembrane potentials of the closed membrane structures. // Dokl. AN UkrSSR. Series B., 1981, N 11, p. 75-77.

44.       Petrenko A. Y., Belois A.M., Lemeshko V.V. The effect of freezing and thawing rates on the functional state and ionic permeability of rat liver mitochondria. // Cryo-letters. l982. v. 3, p. 137-148.

45.       Lemeshko V.V. Conjugation variants of chemical and chemiosmotic mechanisms of oxidative phosphorylation. // Biofizica, l982, v. 37, N 3, p. 420-424.

46.       Petrenko A.Y., Belous A.M., Lemeshko V.V. Effect of the freezing-thawing rates on the functional state and ionic permeability of rat liver mitochondria. // Biokhimia, l982, V. 47, N 4 , p. 626-632.

47.       Lemeshko V.V., Nikitchenko Y.V., Kaliman P.A. Age- induced. lipoperoxidation in liver under rat fasting. // Ukr. Biokhim. Zhurnal, l982, v. 54, N 3, p. 325-327.

48.       Lemeshko V.V., Kaliman P.A., Kultaeva E.V., Kozlova E.V. Phenobarbital-induced changes in the enzymatic activities of the microsomal oxidative system in the rat liver of different age in norm and hyperthyroidism. // Ukr. Biokhim. Zhurnal. l982, v. 54, N 6, p. 653-657.

49.       Lemeshko V.V. Age changes in thyroxine regulation of NADPH-dependent oxidatiive system of rat liver microsomes. // Ukr. Biokhim. Zhurnal, l982, v. 54, N 6, p. 647-652.

50.       Lemeshko V.V., Nikitchenko Y.V. The glutathione S-transferase and the cytochrome P-450 peroxidase activities of liver microsomes during aging of rats. // Dokl. AN UkrSSR. Serie B, l982, N 9, p. 70-72.

51.       Lemeshko V.V., Nikitchenko Y. V. Lipid peroxidation of myocardial membranes and its regulation during aging. // Bull. Eksperim. Biol. i Medicini, l982, N ll, p. 12-14.

52.       Lemeshko V.V., Kaliman P.A., Belostotskaya L.I. Lipofuscin during development and aging of the organism. // Biofizica. l982, v. 37, N 4, p. 733-734.

53.       Lemeshko V.V., Kaliman P.A., Belostotskaya L.I., Uchitel A.A. ATP-synthetase activity, respiration and cytochromes of rat heart mitochondria upon ageing and hyperthyroidism. // Biokhimia, l982, v. 47, N 4, p. 552-559.

54.       Lemeshko V.V. Relationship between structural lability of liver mitochondria outer membrane and the age and sex of rats. // Biofizica, l982, v. 37, N 5, p. 837-840.

55.       Lemeshko V.V., Nikitchenko Y.V. Lipid peroxidation in rat liver mitochondria upon ageing and under hyperthyroidism. // Biokhimia, l982, v. 47, N 5, p. 752-759.

56.       Lemeshko V.V., Nikitchenko Y.V., Kaliman P.A. Activation of liver membrane lipoperoxidation by thyroxine and actinomycin D in young and old rats. // Ukr. Biokhim. Zhurnal, l983, v. 55, N 2, p. 206- 209.

57.       Lemeshko V.V. Calcium-binding activity of heart mitochondria during aging of rats and its possible role in myofibrils relaxation. // Bull. Eksperim. Biol. i Medicini, l983, N 4, p. 42-43.

58.       Lemeshko V.V., Nikitchenko Y.V., Kaliman P.A. Enzymes of liver antioxidant system during ageing of rats. // Ukr. Biokhim. Zhurnal, l983, v. 55, N 5, p. 523-528.

59.      Lemeshko V.V. Changes of ATPsynthase activity of rat liver mitochondria during aging and thyroxine injections. // Ukr. Biokhim. Zhurnal, l983, V. 55, N 5, p. 566-569.

60.      Lemeshko V.V., Kaliman P.A., Kozlova E.V. Age-changes of ethylmorphin demethylase and benzopyrene hydroxilase activities of rat liver microsomes. // Ukr. Biokhim. Zhurnal, l983, V. 55, N 5, p. 569-571.

61.      Lemeshko V.V. Change in the relationship between free and phosphorilating oxidation in rat liver mitochondria during aging. // Dokl. AN UkrSSR. Serie B. l983, N 5, p. 70-72.

62.      Lemeshko V.V. Age peculiarities of the interaction of the fluorescent probes and the thyroxine with the membranes of rat liver microsomes. // Biofizica, l983, v. 38, N 6, p. 985-999.

63.      Lemeshko V.V. About the relationship between the membrane potential and the energisation of mitochondria. // Biofizica, l983, v. 28, N 2, p. 347-348.

64.      Lemeshko V.V. Respiratory chain of mitochondria during organism aging. // Fiziologia i Biokhimia Ontogeneza, Kiev: Edit. Naukova Dumka. l983, p. 138-14l.

65.      Lemeshko V.V., Nikitchenko Y.V., Lankin V.Z. Enzymes of hydroperoxides and O2-’ utilization in the myocardium of rats of different age.// Bull. Eksperim. Biol. i Medicini, l985, N 5, p. 563-565.

66.      Lemeshko V.V.,Kultaeva E.B., Kozlova E.V. Age dependent changes of monoxigenase electron transport system of endoplasmic reticulum membranes of rat liver. // Sistemi Biosinteza Belka i Mexanismi Reguliatsii Funkciy v ontogenese, Kiev: Edit. Naukova Dumka. l985, p. 182-188.

67.      Lemeshko V.V., Babenko N.A., Popova L.Y., Belostotskaya L.I., Kozlova E.V., Kultaeva E.V., Brovkovich V.M., Tsimbal L.V. Structural state of mitochondrial and microsomal membranes of the liver during rats ageing and under the effect of thyroxine. // Ukr. Biokhim. Zhurnal, l986, v. 58, N l, p. 63-68.

68.      Lemeshko V.V., Belostostkaia L.I. Long storage of tightly coupling mitochondria in liquid nitrogen. // Ukr. Biokhim. Zhurnal, l986, v.58, N 3, p. 87-90.

69.      Lemeshko V.V., Nikitchenko Y.V. The level of lipid hydroperoxides in heart and liver or rats of different age. // Ukr. Biokhim. Zhurnal. l986, N 6, p. 67-70.

70.      Lemeshko V.V., Nikitchenko Y.V., Ovciannikov S.E., Svich I.V. Correlation between chemiluminescence and malondialdehyde during lipid peroxidation in liver, heart and brain homogenates in postnatal ontogenesis. // Dokl. AN UkrSSR. Serie B, l986, N 3, p. 60-62.

71.      Lemeshko V.V. Free radical membrane lipoperoxidation and its enzymatic regulation during organism development and aging. // Hadezhnost i Elementarnie Sobitia Processov Starenia Biologicheskix Obektov, Kiev: Edit. Naukova Dumka. l986, p. 143-149.

72.      Lemeshko V.V., Belostotskaia L.I. Energy transformation in rat liver mitochondria during aging. // Mekhanizmi Ontogeneza i ikh Peguliatsia. Kiev: Edit. Naukova Dumka. l987, p. 207-2l2.

73.      Brovkovich V.M., Nikitchenko Y.V., Lemeshko V.V. The damage of Ca 2+ transporting function and lipid membrane component of the sarcoplasmic reticulum in total ischemie of the rat myocardium. // Bull. Eksperim. Biol. i Medicini, l987, N ll, p. 546-548.

74.      Lemeshko V.V., Nikitchenko Y.V., Svich I.V., Ovsyannikov S.E. Membrane lipid peroxidation and its enzymatic regulation during ageing.// Ukr. Biokhim. Zhurnal. l987, v. 59, N 2, p. 50-56.

75.      Novgorodov S.A., Kultaeva E.V., Yaguzhinsky L.S., Lemeshko V.V. Ion permeability induction by the SH cross-linking reagents in rat liver mitochondria is inhibited by the free radical scavenger, butylhydroxytoluene. // J. of Bioenergetics and Biomembranes. l987, v. 19, N 3, p. 191-202.

76.      Lemeshko V.V. Proton-chemical hypothesis of membranous oxidative phosphorylation. // Biokhimia Zhivotnix i Cheloveka. Kiev: Edit. Naukova Dumka. l988, N 12, p. 54-65.

77.      Lemeshko V.V. Do Racker-Stoeckenius experiments exclude possibility of chemical coupling in H+-ATP-synthetase?. // Biofizica, l989, v. 34, N l, p. 14O-14l.

78.      Lemeshko V.V., Malanda P. Mg2+-ejection from heart mitochondria under ischemie: is it a mechanism of defense or damage?. // Ukr. Biokhim. Zhurnal, l989, v. 6l, N l, p. 64-7l.

79.      Lemeshko V.V., Nikitchenko Y. V., Troyanova V.N., Malanda P., Belostostskaya L.I. Peculiarities of ischemic damage of membranes and activation of lipid peroxidation in the myocardium of different age rats. // Ukr. Biokhim. Zhurnal. l989. v. 35, N 2, p. 98-l05.

80.      Lemeshko V.V., Dorkiva E.G., Nikitchenko Y.V., Vasilenko Y.K. Effect of tetracicline and silibore on lipid peroxidation in rat liver tissue of various age groups. // Vopr. Med. Khimii, l989, v. 35, N 5, p. 49-54.

81.      Lemeshko V.V., Strelyany S.M. Membrane regulation of mitochondrial respiration and ATP hydrolysis in brain homogenates of rats of various age. // Neirokhimia. l990. v. 9, N l, p. 47-56.

82.      Lemeshko V.V. Mitochondrial Ca-transport system and its role in the regulation of oxidative metabolism. // Biokhimia Zhivotnix i Cheloveka., Kiev: Edit. Naukova Dumka. l990, N l4, p. 23-33.

83.      Lemeshko V.V., Nikitchenko Y.V., Padalko V.I., Belostostkaya L.I. Energy transformation in mitochondria, monoxigenase system and lipid peroxidation in rat liver during life-span prolongation of rats by calorie-restricted diet. // Provlemi Starenia i Dolgaletia, l99l. N l, p. 11-18.

84.      Lemeshko V.V., Brovkovich V.M., Listopad A.P. Simple method for estimation of phospholipids in biological objects. // Ukr. Biokhim. Zhurnal. l99l. v. 63, N l. p. 60-66.

85.      Shekh V.E., Lemeshko V.V. Multiple activation performed by Mg 2+ ions of electron transport between the external and internal mitochondrial membranes. // Dokl. AN UkrSSR. l99l, N 2, p. 44-46.

86.      Udovikova E.A., Lemeshko V.V. The age differences of influence of osmotic pressure upon the respiration of mitochondria of the liver of rats. // Bull. Eksperim. Biol. i Medicini, l99l, N 2, p. 150-152.

87.      Belostotskaya L.I., Lemeshko V.V. Respiration and oxidative phosphorylation of rat liver mitochondria under experimental life prolongation. // Dok. AN UkrRSR, l99l. N l. p. l35-137.

88.      Lemeshko V.V., Belostoskaya L.I. Decrease of phosphorylating oxidation and increase of heat producing NADH oxidation in rat liver mitochondria during life-span prolongation of rats by calorie-restricted diet. // Mech. Ageing and Dev., l992, v. 63, N l, p. 79-89.

89.      Lemeshko V.V., Udovikova E.A. Influence of the osmotic pressure on the oligomycin-sensitive ATPase activity and Mg2+ release from the liver mitochondria of rats of different age groups. // Ukr. Biokhim. Zhurnal, l992, v. 64, N l, p. 83-88.

90.      Udovikova E.A., Lemeshko V.V. Age dependent peculiarities of spontaneous high amplitude swelling of the rat liver mitochondria. // Dokl. AN UkrSSR. l992, N 8, p. 155- 157.

91.      Lemeshko V.V. Bioenergetic aspects of aging mechanisms. // Izvestia RAN. Seria Biol., l982, v. 4, p. 648-649.

92.      Lemeshko V.V. Mitochondria and mechanisms of aging. // Biokhimia i Fisiologia Vozrastnogo Rasvitia Organisma. Kiev: Edit. Naukova Dumka.l992, p. 274-282.

93.      Mironova N.G., Lemeshko V.V. Cryoinjuries and subsequent recovery of rat liver mitochondria: age peculiarities. // Provlemi Starenia i Dolgoletia, l992, v. 2, N 4, p. 36l-369.

94.      Lemeshko V.V., Mironova N.G. The reversible cryoactivation of unspecific protein pore as a possible mechanism of cryouncopling and reparation of the system of oxidative phosphorylation in mitochondria. // Problems of Cryobiology, l993. N 3, p. 12-18.

95.      Lemeshko V.V., Shekh V.E. Hypotonic fragility of outer membrane and activation of external pathway of NADH oxidation in rat liver mitochondria are increased with age. // Mech. Ageing and Dev. l993, v. 68, N l-3, p. 221-l23.

96.      Padalko V.I., Kozlova E.V., Lemeshko V.V. The ischemic injuries of monooxygenase system functions in the liver of rats of various age.// Problemi Starenia i Dolgoletia. l993, v. 3, N 4, p. 318-325.

97.      Shekh V.E., Lemeshko V.V. Phosphate-dependent swelling of mitochondria as a factor of activation of rotenone-insensitive NADH oxidation. // Biologicheskie Membrani. l995, v. 12, N 4, p. 39l-399.

98.      Lemeshko V.V., Shekh V.E., Aleksenko T.V. Intermembrane electron transfer during high amplitude swelling of rat liver mitochondria. // Ukr. Biokhim. Zhurnal, l995, v. 67, N 2, p. 28-34.

99.        Shekh V.E., Alexsenko T.V., Lemeshko V.V. Mitochondrial intermembrane electron transport during rotenon-insensitive NADH oxidation in liver homogenates. // Dokl. AN UkrSSR. Serie B. l995, N 5, p. 112-114.

100.     Lemeshko V.V., Shekh V.E., Udovikova E.A. Effect of the experimental ischemie of rat liver on high amplitude swelling of mitochondria and their outer membrane disrupture. // School of Fundamental Medicine Journal, l995, v. l, N 1, p. 23-27.

101.     Nikitchenko Yu.V., Dzuba V.N., Lemeshko V.V. Protective effect of some natural metabolites under ishcemia of rat hearts. // School of Fundamental Medicine Journal, 1996, v. 2, N1, p. 24-27.

102.     Padalko V.I., Sukhodub A.L., Kozlova E.V., Lemeshko V.V. Hepatoprotective properties of propolis on experimental toxic liver injury //Liki (Drugs), 1996, N2, 74-79. Kiev.

103.     Shekh V.E., Lemeshko V.V. Phosphate-dependent swelling of mitochondria as a factor of activation of rotenone-insensitive NADH oxidation. // Membrane and Cell Biology. l996, v. 9, N 4, p. 405-414.

104.     Lemeshko V.V., Sukhodub A.L. Irreversible changes in cytochrome P-420 differential spectrum amplitude in microsomal membranes. New properties of Cu(II)-EDTA complex. // Ukr. Biokhim. Zhurnal, l997, v. 69, N 2, p. 120-125.

105.     Anishkin A.G., Lemeshko V.V. The mathematical modeling of proton-chemical unit of coupling oh ATP synthesis with electron transport in biomembranes. // School of Fundamental Medicine J. , 1997, v. 3, N1, p. 4-9.

106.   Lemeshko V.V., Anishkin A.G. Mathematical modeling of energy coupling in mitochondria in frames of proton-chemical hypothesis. // Biofizica, l998, v. 43, N 2. p. 308-314.

107.   Lemeshko V.V., Sukhodub A.L. Character and possible mechanism of destructive action of Cu(II)-EDTA chelative complex on cytochrome P-450(420) of rat liver microsomal membranes. // Revista Colombiana de Física, 1997 ( in press ).

108.   Lemeshko V.V., Anishkin A.G. Computer analysis of proton-chemical hypothesis of energy coupling in biomembranes. //Revista Colombiana de Física, 1997 ( in press).

 

ACKNOWLEDGEMENTS

 

Active member of the New-York Academy of Sciences

Member of International Society for Heart Research

Member of Ukrainian Biochemical Society

Member of Ukrainian Biophysical Society

Member of Colombian Biophysical Society