THEORETICAL DEPENDENCE OF PHOSPHATE POTENTIAL ON

MAGNITUDE OF PROTONMOTIVE FORCE FOR TWO-ELECTRON

PROTON-CHEMICAL COUPLING POINT MODEL.

A.G. Anishkin, V.V. Lemeshko.

Biology Research Institute of Kharkov StateUniversity. 310077, Kharkov, 4 Svobody Sq.

Received September 23, 1998.

• In the work the electrical model of a two-electronic proton-chemical coupling point is considered. The computer analysis of the model shows that for mitochondria in respiration state 4 (by Chance) the ratio of the phosphate potential to the proton-motive force grows as the concentration of an uncoupler in the medium increases. The obtained theoretical dependence correlates qualitatively with experimental data contradicting to the chemiosmotic hypothesis.

  KEYWORDS: respiration, oxidative phosphorylation, coupling mechanism, mathematical modelling.