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THE MATHEMATICAL MODELING OF ENERGY COUPLING IN MITOCHONDRIA IN FRAMES OF PROTON-CHEMICAL HYPOTHESIS .

V.V.Lemeshko, A.G.Anishkin.

Kharkov State University

Biology Research Institute.


Summary

The dependence of ATP-synthesis and mitochondria respiration rates on membrane potential is analyzed in frames of proton-chemical hypothesis of oxidative phosphorylation. The mathematical and electrical models of the unit of energy coupling are proposed. Computer analysis of the mathematical model allowed to obtain the theoretical dependence of the rates of ATP synthesis and of the respiration on membrane potential that are in good qualitative agreement with experimental data, contradicting chemiosmotic hypothesis.